By Leda R. Castilho
Creation to animal mobilephone expertise /, Animal cells: simple innovations /, Cloning and expression of heterologous proteins in animal cells /, telephone metabolism and its keep an eye on in tradition /, tradition media for animal cells /, Post-translational amendment of recombinant proteins /, Mechanisms of mobile proliferation and mobile dying in animal phone tradition in vitro /, Mathematical types for progress and product synthesis in animal mobile tradition /, Bioreactors for animal cells /, tracking and keep an eye on of telephone cultures /, Animal cellphone separation /, Product purification tactics /, qc of biotechnological items /, Regulatory features /, highbrow estate /, Recombinant healing proteins /, Monoclonal antibodies /, Viral vaccines: thoughts, rules, and bioprocesses /, Bioinsecticides /, telephone treatments and stem cells /, Gene treatment /; Paula Marques Alves, Manuel Jose Teixeira Carrondo, & Pedro Estilita Cruz --, Patricia Leo ... [et al.] --, Mariela Bollati-Fogolin & Marcelo A. Comini --, Paola Amable & Michael Butler --, Angela Maria Moraes, Ronaldo Zucatelli Mendonca, & Claudio Alberto Torres Suazo --, Michael Butler --, Maira Peixoto Pellegrini, Rodrigo Coelho Ventura Pinto, & Leda dos Reis Castilho --, Elisabeth F.P. Augusto, Manuel F. Barral, & Rosane A.M. Piccoli --, Ernesto Chico Veliz, Gryssell Rodriguez, & Alvio Figueredo Cardero --, Aldo Tonso --, Leda dos Reis Castilho & Ricardo de Andrade Medronho --, Angela Maria Moraes, Leda Castilho, & Sonia Maria Alves Bueno --, Marina Etcheverrigaray & Ricardo Kratje --, Maria Teresa Alves Rodrigues & Ana Maria Moro --, Ana Cristina Almeida Muller & Leila Costa Duarte Longa --, Maria Candida Maia Mellado & Leda dos Reis Castilho --, Wirla M.S.C. Tamashiro & Elisabeth F.P. Augusto --, Isabel Maria Vicente Guedes de Carvalho Mello ... [et al.] --, Marcia Regina da Silva Pedrini & Ronaldo Zucatelli Mendonca --, Hamilton da Silva Jr. & Radovan Borojevic --, Celio Lopes Silva ... [et al.]
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Additional info for Animal cell technology: from biopharmaceuticals to gene therapy
Merten O-W, Cruz PE, Rochette C, Geny-Fiamma C, Bouquet C, Gonc¸alves D, Danos O, Carrondo MJT (2001), Comparison of different bioreactor systems for the production of high titer retroviral vectors, Biotechnol. Prog. 17:326–335. html, accessed in February 2006. Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS, McBridge OW, Leonard WJ (1993), Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeﬁciency in humans, Cell 73:147–157. Powers MJ, Janigian DM, Wack KE, Baker CS, Beer Stolz D, Grifﬁth LG (2002), Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor, Tissue Eng.
1 1 The ﬁrst therapeutic antibody approved (Orthoclone OKT-3 or Muromonab CD3, 1986) was indicated not for cancer treatment, but for controlling acute rejection of transplanted organs (kidney, heart, and liver). Nowadays, other clinical indications such as asthma, rheumatoid arthritis, psoriasis, and Crohn’s disease are treated with mAbs (see Chapter 17) (Antibody Engineering and Manufacture, 2005; Monoclonal Antibodies and Therapies, 2004; Hot Drugs, 2004; Walsh, 2004). Many recombinant proteins that are not antibodies are also on the market for distinct applications (see Chapter 16).
Vero cells (a cell line derived from monkey) were used for anti-rabies vaccine. Hybridomas were considered acceptable for mAb production and the use of genetically modiﬁed CHO (Chinese hamster ovary) cells was authorized for the production of tissue plasminogen activator (tPA) by Genentech in 1986. Finally, three relevant aspects should be mentioned to clarify the scientiﬁc, technological, and industrial position of biopharmaceuticals and animal cells. (i) Complex biopharmaceuticals, such as proteins, virus or virus-like particles (VLPs), among others, produced by cellular and/or recombinant technologies are characterized/deﬁned by their own production processes.
Animal cell technology: from biopharmaceuticals to gene therapy by Leda R. Castilho