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Furthermore, it was observed that the extent of adherence of SS RBC to cultured endothelial cells appear to parallel the clinical severity of vasoocclusive events in SCD (Hebbel et al. 1980a). Subsequently, these studies have been confirmed using a flow system (Barabino et al. 1987) and an in vivo animal model system (Kaul et al. 1989). It has been shown that adhesion of SS RBC to endothelium occurs at venular wall shear rates (Kaul et al. 1995; Barabino et al. 1987), and it is the postcapillary venules where SS RBC adhere in the animal models (Kaul et al.

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