Advances in Immunology, Vol. 55 by Frank J. Dixon PDF

By Frank J. Dixon

ISBN-10: 0120224550

ISBN-13: 9780120224555

From the reports of earlier Volumes "Provides unrivalled price in either educational and monetary phrases and may be bought by means of tough pressed librarians as a tremendous precedence to be jealously defended." -JOURNAL OF clinical MICROBIOLOGY "Advances in Immunology needs to locate itself one of the so much energetic volumes within the libraries of our universities and institutions." -SCIENCE "A provocative and scholarly overview of research." -JOURNAL OF the yankee scientific organization "Deserves an enduring position in biomedical libraries as an relief in study and in teaching." -JOURNAL OF IMMUNOLOGIC tools

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Extra resources for Advances in Immunology, Vol. 55

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Lev et al. (1991)investigated the signal transduction mediated by a chimeric receptor kinase composed of the extracellular ligand-binding domain of the epidermal growth factor (EGF) receptor and the transmembrane and cytoplasmic domains of the SCFR. They demonstrated that on binding EGF, the ligand-receptor complex underwent endocytosis and degradation, and showed that the activated SCFR kinase strongly associated with PI3'K and an 85-kDa phosphoprotein and coupled to PLC-yl and the Raf-1 protein kinase, but did not significantly change levels of inositol phosphate.

6 in testis, and 26:l in brain. KL-1 was the predominant transcript in BALBIc 3T3 fibroblasts, which exhibited barely detectable KL-2, as well as in adult mouse thymus. ) and heart. When production of soluble KL by COS cells transfected with KL-1 or KL-2 expression constructs was measured, both KL-1 and KL-2 released soluble products, but the KL-2-derived product appeared in 32 STEPHEN J . GALL1 ET AL. the cellular supernatants at later intervals and in lower amounts than did the KL-l-derived product.

This represents one example of how some cytokines might antagonize SCF-dependent augmentation of hematopoiesis. Second, b y transfecting various forms of human SCF into immortalized stromal cell lines derived from the livers of SZISZ embryos, Toksoz et al. (1992) showed that either soluble SCF or membrane-associated SCF can increase the numbers of human hematopoietic progenitor cells present in these coculture systems. However, hematopoiesis was supported for much longer periods in uitro in cultures in which the stromal cell layer expressed membrane-associated SCF.

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Advances in Immunology, Vol. 55 by Frank J. Dixon


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