By George F. Vande Woude; George Klein (Eds.)
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Extra resources for Advances in Cancer Research
Among variety of cancers, the correlation between calcium ion (Ca2þ) and cancer incidence in man was observed for prostate cancer (Skinner and Schwartz, 2009). Actually, this suggests that prospective association between serum calcium and prostate cancer mortality exist. , 1998). , 2009). , 2001, 2003). , 2004; Pajak and Orzechowski, 2007a). , 1998). Besides, since secretory activity relies on Ca2 þ influx (Catterall, 2000), intracellular CLU accumulation might be brought about by low intracellular calcium.
2001). , 2003). It has been recently demonstrated that FASN is overexpressed also in prostate intraepithelial neoplasia (PIN) compared with adjacent normal tissue, suggesting that it plays a role in the initial phases of prostate tumorigenesis, and in metastatic prostate cancer, suggesting that it may function as a mediator of biological aggressiveness. , 2003) demonstrated that FASN-overexpressing prostate cancers display a characteristic gene expression signature, indicating a particular transcription pattern related to its activity.
Previously, Caccamo et al. (2004) showed identical reaction in human prostate cells when BAPTA AM was utilized to eliminate intracellular calcium. BAPTA AM is a well-known intracellular calcium blocker that enters the cell, is cleaved and trapped irreversibly as charged Ca2þ chelator. , 2005). It is not clear, if intracellular Ca2þ depletion, or Ca2þ influx from the outside elicit cell death. The risk of BAPTA toxicity at higher doses may also be attributed to Ca2þ deprivation from ER as BAPTA can enter this compartment.
Advances in Cancer Research by George F. Vande Woude; George Klein (Eds.)