Download e-book for iPad: Adoptive immunotherapy : methods and protocols by Burkhard Ludewig, Matthias W. Hoffmann

By Burkhard Ludewig, Matthias W. Hoffmann

ISBN-10: 1588294064

ISBN-13: 9781588294067

ISBN-10: 1592598625

ISBN-13: 9781592598625

An authoritative selection of optimum innovations for generating and characterizing the immunologically energetic cells and effector molecules now gaining extensive use within the scientific remedy of sufferers. making the most of the most recent applied sciences, the authors current simply reproducible experimental protocols for the learn of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and scientific purposes and at the growth of chosen ways in medical trials. extra chapters conceal the molecular definition of aim antigens, mathematical modeling ways to immunotherapy, and the usage of regulatory T cells. The protocols give the opportunity to check the adoptive move of adapted antigen-specific immune cells and to enhance the medical software of adoptive immunotherapy.

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Extra resources for Adoptive immunotherapy : methods and protocols

Sample text

Immunol. 2, 175–184. 127. , et al. (2003) Role of toll-like receptors in costimulating cytotoxic T cell responses. Eur. J. Immunol. 33, 1465–1470. Mathematical Approach to DC Immunotherapy 19 2 A Mathematical Approach for Optimizing Dendritic Cell-Based Immunotherapy Gennady Bocharov, Neville J. Ford, and Burkhard Ludewig Summary Adoptive dendritic cell (DC)-based immunotherapy represents a promising approach to overcome peripheral tolerance against autologous tumor antigens and to maintain protective antitumor immunity.

Immunol. 31, 3432–3442. 114. , et al. (2001) Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals. J. Virol. 75, 2142–2153. 115. , and Mule, J. J. (2001) Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization. Cancer Res. 61, 8105–8109. Dendritic Cells and Immunotherapy 17 116. , et al. (2000) Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells.

31, 3432–3442. 114. , et al. (2001) Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals. J. Virol. 75, 2142–2153. 115. , and Mule, J. J. (2001) Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization. Cancer Res. 61, 8105–8109. Dendritic Cells and Immunotherapy 17 116. , et al. (2000) Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells.

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Adoptive immunotherapy : methods and protocols by Burkhard Ludewig, Matthias W. Hoffmann


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